Structural determinants and specificities for ROMK1-phosphoinositide interaction
نویسندگان
چکیده
منابع مشابه
Structural determinants and specificities for ROMK1-phosphoinositide interaction.
We have recently reported that direct interaction between phosphatidylinositol bisphosphate (PIP(2)) and the COOH-terminal cytoplasmic domain of ROMK1 is important for opening of the channel. We identified arginine-188 of ROMK1 as a critical residue for this interaction. Here, we further report that substitution of a neutral amino acid for lysine-181, arginine-217, or lysine-218 decreases singl...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2002
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00300.2001